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Target
M-phase inducer phosphatase 2
Ligand
BDBM26617
Substrate
n/a
Meas. Tech.
ChEMBL_1813330 (CHEMBL4312904)
Ki
5300±n/a nM
Citation
 Cerchia, C; Nasso, R; Mori, M; Villa, S; Gelain, A; Capasso, A; Aliotta, F; Simonetti, M; Rullo, R; Masullo, M; De Vendittis, E; Ruocco, MR; Lavecchia, A Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines. J Med Chem 62:7089-7110 (2019) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 2
Synonyms:
CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN
Type:
Protein
Mol. Mass.:
64985.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
580
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
  
Inhibitor
Name:
BDBM26617
Synonyms:
4-[(2-carboxyphenyl)carbonyl]benzene-1,2-dicarboxylic acid | Compound 28620
Type:
Small organic molecule
Emp. Form.:
C16H10O7
Mol. Mass.:
314.2464
SMILES:
OC(=O)c1ccccc1C(=O)c1ccc(C(O)=O)c(c1)C(O)=O
Structure:
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