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Target
M-phase inducer phosphatase 3
Ligand
BDBM50504277
Substrate
n/a
Meas. Tech.
ChEMBL_1814178 (CHEMBL4313752)
IC50
210±n/a nM
Citation
 Jing, L; Wu, G; Hao, X; Olotu, FA; Kang, D; Chen, CH; Lee, KH; Soliman, MES; Liu, X; Song, Y; Zhan, P Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. Eur J Med Chem 183:0 (2019) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 3
Synonyms:
CDC25C | Dual specificity phosphatase Cdc25C | M-phase inducer phosphatase 3 | MPIP3_HUMAN
Type:
Substrate
Mol. Mass.:
53366.11
Organism:
Homo sapiens (Human)
Description:
P30307
Residue:
473
Sequence:
MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANLSILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMKCSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNPNLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDKVKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQDLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP
  
Inhibitor
Name:
BDBM50504277
Synonyms:
CHEMBL4566962
Type:
Small organic molecule
Emp. Form.:
C20H13ClN6O2
Mol. Mass.:
404.809
SMILES:
ClC1=C(NCc2cn(Cc3cccc(c3)C#N)nn2)C(=O)c2ncccc2C1=O |c:1|
Structure:
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