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Target
RNA-directed RNA polymerase
Ligand
BDBM50504496
Substrate
n/a
Meas. Tech.
ChEMBL_1814874 (CHEMBL4314448)
IC50
390±n/a nM
Citation
 Hassan, GS; Georgey, HH; Mohammed, EZ; Omar, FA Anti-hepatitis-C virus activity and QSAR study of certain thiazolidinone and thiazolotriazine derivatives as potential NS5B polymerase inhibitors. Eur J Med Chem 184:0 (2019) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50504496
Synonyms:
CHEMBL4456569
Type:
Small organic molecule
Emp. Form.:
C19H15FN2O4S
Mol. Mass.:
386.397
SMILES:
COc1ccc(NC(=O)CN2C(=O)S\C(=C/c3ccc(F)cc3)C2=O)cc1
Structure:
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