Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50504503
Substrate
n/a
Meas. Tech.
ChEMBL_1814874 (CHEMBL4314448)
IC50
540±n/a nM
Citation
 Hassan, GS; Georgey, HH; Mohammed, EZ; Omar, FA Anti-hepatitis-C virus activity and QSAR study of certain thiazolidinone and thiazolotriazine derivatives as potential NS5B polymerase inhibitors. Eur J Med Chem 184:0 (2019) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50504503
Synonyms:
CHEMBL4546969
Type:
Small organic molecule
Emp. Form.:
C20H19N3O3S
Mol. Mass.:
381.448
SMILES:
COc1ccc(\C=c2\sc3=NCN(Cn3c2=O)c2ccc(OC)cc2)cc1 |t:9|
Structure:
Search PDB for entries with ligand similarity: