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Target
Delta(7)-sterol 5(6)-desaturase
Ligand
BDBM50055276
Substrate
n/a
Meas. Tech.
ChEMBL_260 (CHEMBL615701)
IC50
114000±n/a nM
Citation
 Goldstein, AS; Frye, LL Synthesis and bioevaluation of delta 7-5-desaturase inhibitors, an enzyme late in the biosynthesis of the fungal sterol ergosterol. J Med Chem 39:5092-9 (1997) [PubMed]  Article 
Target
Name:
Delta(7)-sterol 5(6)-desaturase
Synonyms:
ERG3 | ERG3_CANAX | Sterol-C5-desaturase
Type:
PROTEIN
Mol. Mass.:
45449.27
Organism:
Candida albicans
Description:
ChEMBL_10249
Residue:
386
Sequence:
MDIVLEICDYYLFDKVYADVFPKDGAVHEFLKPAIQSFSQIDFPSLPNLDSFDTNSTLISSNNFNISNVNPATIPSYLFSKIASYQDKSEIYGLAPKFFPATDFINTSFLARSNIFRETLSLFIITTIFGWLLYFIVAYLSYVFVFDKKIFNHPRYLKNQMSLEIKRATTAIPVMVLLTIPFFLLELNGYSFLYLDINECTGGYKAILWQIPKFILFTDCGIYFLHRWLHWPSVYKVLHKPHHKWIVCTPFASHAFHPVDGFFQSLPYHLYPLLFPLHKVLYLFLFTFVNFWTVMIHDGSYWSNDPVVNGTACHTVHHLYFNYNYGQFTTLWDRLGNSYRRPDDSLFVKDVKAEEEKKIWKEQTRKMEEIRGEVEGKVDDREYVEQ
  
Inhibitor
Name:
BDBM50055276
Synonyms:
(4aR,6S,8aR)-6-Hydroxy-8a-methyl-2,4,5,6,7,8,8a,8b-octahydro-1H-cyclobuta[a]naphthalene-4a-carboxylic acid amide | CHEMBL148676
Type:
Small organic molecule
Emp. Form.:
C14H21NO2
Mol. Mass.:
235.322
SMILES:
C[C@]12CC[C@H](O)C[C@@]1(CC=C1CCC21)C(N)=O |t:10|
Structure:
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