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Target
Phospholipase A2, membrane associated
Ligand
BDBM50055363
Substrate
n/a
Meas. Tech.
ChEMBL_156192 (CHEMBL761443)
IC50
306±n/a nM
Citation
 Dillard, RD; Bach, NJ; Draheim, SE; Berry, DR; Carlson, DG; Chirgadze, NY; Clawson, DK; Hartley, LW; Johnson, LM; Jones, ND; McKinney, ER; Mihelich, ED; Olkowski, JL; Schevitz, RW; Smith, AC; Snyder, DW; Sommers, CD; Wery, JP Indole inhibitors of human nonpancreatic secretory phospholipase A2. 2. Indole-3-acetamides with additional functionality. J Med Chem 39:5137-58 (1997) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50055363
Synonyms:
5-(1-Benzyl-3-carbamoylmethyl-2-methyl-1H-indol-6-yloxy)-pentanoic acid ethyl ester | CHEMBL262428
Type:
Small organic molecule
Emp. Form.:
C25H30N2O4
Mol. Mass.:
422.5167
SMILES:
CCOC(=O)CCCCOc1ccc2c(CC(N)=O)c(C)n(Cc3ccccc3)c2c1
Structure:
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