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Target
D(2) dopamine receptor
Ligand
BDBM50055725
Substrate
n/a
Meas. Tech.
ChEMBL_62399 (CHEMBL872888)
Ki
8.7±n/a nM
Citation
 Wustrow, DJ; Smith, WJ; Corbin, AE; Davis, MD; Georgic, LM; Pugsley, TA; Whetzel, SZ; Heffner, TG; Wise, LD 3-[[(4-Aryl-1-piperazinyl)alkyl]cyclohexyl]-1H-indoles as dopamine D2 partial agonists and autoreceptor agonists. J Med Chem 40:250-9 (1997) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50055725
Synonyms:
3-{4-[2-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-cyclohexyl}-1H-indole | CHEMBL86662
Type:
Small organic molecule
Emp. Form.:
C27H32N2
Mol. Mass.:
384.5564
SMILES:
C(CN1CCC(=CC1)c1ccccc1)[C@H]1CC[C@@H](CC1)c1c[nH]c2ccccc12 |wU:17.22,wD:14.15,c:5,(13.38,-6.35,;14.7,-7.12,;16.04,-6.35,;17.37,-7.12,;18.7,-6.35,;18.68,-4.79,;17.33,-4.04,;16.02,-4.81,;20.02,-4.02,;21.34,-4.79,;22.68,-4.01,;22.66,-2.47,;21.33,-1.71,;20,-2.48,;12.04,-7.1,;10.71,-6.33,;9.38,-7.1,;9.38,-8.63,;10.71,-9.4,;12.03,-8.64,;8.09,-9.47,;8.03,-11.04,;6.54,-11.43,;5.69,-10.15,;4.15,-9.91,;3.6,-8.47,;4.59,-7.28,;6.1,-7.51,;6.65,-8.95,)|
Structure:
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