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Target
Potassium channel subfamily K member 3
Ligand
BDBM50017659
Substrate
n/a
Meas. Tech.
ChEMBL_1822392 (CHEMBL4322156)
IC50
668000±n/a nM
Citation
 Bedoya, M; Rinné, S; Kiper, AK; Decher, N; González, W; Ramírez, D TASK Channels Pharmacology: New Challenges in Drug Design. J Med Chem 62:10044-10058 (2019) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 3
Synonyms:
Acid-sensitive potassium channel TASK-1 | Acid-sensitive potassium channel protein TASK-1 | KCNK3 | KCNK3_HUMAN | Potassium channel protein TASK-1 | Potassium channel subfamily K member 3 | Potassium channel subfamily K member 3 (TASK-1) | TASK | TASK1 | TWIK-related acid-sensitive K(+) channel 1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1
Type:
Protein
Mol. Mass.:
43534.71
Organism:
Homo sapiens (Human)
Description:
O14649
Residue:
394
Sequence:
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
  
Inhibitor
Name:
BDBM50017659
Synonyms:
2-(Dimethylamino)ethyl p-(butylamino)benzoate | 2-(dimethylamino)ethyl 4-(butylamino)benzoate | CHEMBL698 | Diaethylaminoaethanol ester der p-butylaminobenzoesaeure | TETRACAINE | p-Butylaminobenzoyl-2-dimethylaminoethanol
Type:
Small organic molecule
Emp. Form.:
C15H24N2O2
Mol. Mass.:
264.3633
SMILES:
CCCCNc1ccc(cc1)C(=O)OCCN(C)C
Structure:
Search PDB for entries with ligand similarity: