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Target
Potassium channel subfamily K member 5
Ligand
BDBM50123519
Substrate
n/a
Meas. Tech.
ChEMBL_1822389 (CHEMBL4322153)
IC50
12000±n/a nM
Citation
 Bedoya, M; Rinné, S; Kiper, AK; Decher, N; González, W; Ramírez, D TASK Channels Pharmacology: New Challenges in Drug Design. J Med Chem 62:10044-10058 (2019) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 5
Synonyms:
Acid-sensitive potassium channel protein TASK-2 | KCNK5 | KCNK5_HUMAN | Potassium channel subfamily K member 5 | TASK2 | TWIK-related acid-sensitive K(+) channel 2
Type:
PROTEIN
Mol. Mass.:
55130.28
Organism:
Homo sapiens
Description:
ChEMBL_118907
Residue:
499
Sequence:
MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKILEVVSDAAGQGVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPFVFMVTEGWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQVKGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLVPLVVYSKNRVPTLEEVSQTLRSKGHVSRSPDEEAVARAPEDSSPAPEVFMNQLDRISEECEPWDAQDYHPLIFQDASITFVNTEAGLSDEETSKSSLEDNLAGEESPQQGAEAKAPLNMGEFPSSSESTFTSTESELSVPYEQLMNEYNKANSPKGT
  
Inhibitor
Name:
BDBM50123519
Synonyms:
2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylic acid 2,4-difluoro-benzylamide | CHEMBL148342
Type:
Small organic molecule
Emp. Form.:
C30H26F2N2O3
Mol. Mass.:
500.5358
SMILES:
COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2C(=O)NCc2ccc(F)cc2F)cc1
Structure:
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