Reaction Details Report a problem with these data
Target
Potassium channel subfamily K member 9
Ligand
BDBM50426570
Substrate
n/a
Meas. Tech.
ChEMBL_1822387 (CHEMBL4322151)
IC50
10.0±n/a nM
Citation
 Bedoya, M; Rinné, S; Kiper, AK; Decher, N; González, W; Ramírez, D TASK Channels Pharmacology: New Challenges in Drug Design. J Med Chem 62:10044-10058 (2019) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 9
Synonyms:
Acid-sensitive potassium channel protein TASK-3 | KCNK9_RAT | Kcnk9 | Potassium channel subfamily K member 9 | TWIK-related acid-sensitive K(+) channel 3 | Task3 | Two pore K(+) channel KT3.2 | Two pore potassium channel KT3.2
Type:
PROTEIN
Mol. Mass.:
44364.88
Organism:
Rattus norvegicus
Description:
ChEMBL_100113
Residue:
396
Sequence:
MKRQNVRTLSLIACTFTYLLVGAAVFDALESDHEMREEEKLKAEEVRLRGKYNISSDDYQQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTEVSMENMVTVGFFSCMGTLCLGAAAFSQCEDWSFFHAYYYCFITLTTIGFGDFVALQSKGALQRKPFYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNTDEDLLEGEVAQILAGNPRRVVVRVPQSRKRHHPMYFLRKYGRTLCYLCFPGANWGDDDDDDDDAVENVVVTTPVPPAVAAAAAAATPGPSTRNVRATVHSVSCRVEEIPPDVLRNTYFRSPFGAIPPGMHTCGENHRLHIRRKSI
  
Inhibitor
Name:
BDBM50426570
Synonyms:
CHEMBL2324344
Type:
Small organic molecule
Emp. Form.:
C29H32N4O2
Mol. Mass.:
468.59
SMILES:
CCCC(=O)C1CCN(CC1)c1ncnc2CCN(Cc12)C(=O)c1ccc(cc1)-c1ccccc1
Structure:
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