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Target
Potassium channel subfamily K member 9
Ligand
BDBM79212
Substrate
n/a
Meas. Tech.
ChEMBL_1822397 (CHEMBL4322161)
IC50
45500±n/a nM
Citation
 Bedoya, M; Rinné, S; Kiper, AK; Decher, N; González, W; Ramírez, D TASK Channels Pharmacology: New Challenges in Drug Design. J Med Chem 62:10044-10058 (2019) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 9
Synonyms:
Acid-sensitive potassium channel protein TASK-3 | KCNK9 | KCNK9_HUMAN | TASK3 | TWIK-related acid-sensitive K(+) channel 3 | Two pore K(+) channel KT3.2 | Two pore potassium channel KT3.2
Type:
PROTEIN
Mol. Mass.:
42276.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1457494
Residue:
374
Sequence:
MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYRQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHSFTDHQRLMKRRKSV
  
Inhibitor
Name:
BDBM79212
Synonyms:
(2R,3R)-2-(diphenylmethyl)-N-[(2-iodanylphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine;ethanedioic acid;hydrate | (2R,3R)-2-(diphenylmethyl)-N-[(2-iodophenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine;oxalic acid;hydrate | (2R,3R)-2-benzhydryl-N-[(2-iodophenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine;oxalic acid;hydrate | L-703,606 oxalate salt hydrate | MLS002172464 | SMR001254095 | [(2R,3R)-2-benzhydrylquinuclidin-3-yl]-(2-iodobenzyl)amine;oxalic acid;hydrate | cid_25102597
Type:
Small organic molecule
Emp. Form.:
C27H29IN2
Mol. Mass.:
508.437
SMILES:
[H]C12CCN(CC1)[C@H](C(c1ccccc1)c1ccccc1)[C@@H]2NCc1ccccc1I |wD:21.25,7.8,TLB:8:7:2.3:6.5,THB:22:21:2.3:6.5,(14.16,2.4,;13.66,3.85,;9.83,2.16,;10.6,.83,;13.27,2.37,;16.09,1.2,;16.49,2.69,;11.76,5.16,;10.27,5.56,;9.87,7.05,;10.96,8.14,;10.56,9.62,;9.08,10.02,;7.99,8.93,;8.39,7.45,;8.88,4.91,;7.61,5.79,;6.22,5.14,;6.08,3.61,;7.35,2.72,;8.74,3.37,;13.09,5.93,;13.49,7.42,;14.98,7.82,;15.38,9.31,;14.29,10.39,;14.69,11.88,;16.18,12.28,;17.26,11.19,;16.87,9.7,;17.95,8.61,)|
Structure:
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