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Target
Spindlin-3
Ligand
BDBM50505574
Substrate
n/a
Meas. Tech.
ChEMBL_1823327 (CHEMBL4323091)
Kd
131±n/a nM
Citation
 Fagan, V; Johansson, C; Gileadi, C; Monteiro, O; Dunford, JE; Nibhani, R; Philpott, M; Malzahn, J; Wells, G; Faram, R; Cribbs, AP; Halidi, N; Li, F; Chau, I; Greschik, H; Velupillai, S; Allali-Hassani, A; Bennett, J; Christott, T; Giroud, C; Lewis, AM; Huber, KVM; Athanasou, N; Bountra, C; Jung, M; Schüle, R; Vedadi, M; Arrowsmith, C; Xiong, Y; Jin, J; Fedorov, O; Farnie, G; Brennan, PE; Oppermann, U A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J Med Chem 62:9008-9025 (2019) [PubMed]  Article 
Target
Name:
Spindlin-3
Synonyms:
SPIN-3 | SPIN3 | SPIN3_HUMAN | Spindlin-3 | Spindlin-like protein 3
Type:
PROTEIN
Mol. Mass.:
29208.24
Organism:
Homo sapiens
Description:
ChEMBL_119075
Residue:
258
Sequence:
MKTPFGKAAAGQRSRTGAGHGSVSVTMIKRKAAHKKHRSRPTSQPRGNIVGCRIQHGWKDGDEPLTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELHRDERVSSLEVLPNRVASSRISDTHLAEIMVGKAVEHIFETEEGSKNEWRGMVLAQAPVMNTWFYITYEKDPVLYMYQLLDDYKDGDLRILQDSNDSPLAEREPGEVIDSLVGKQVEYAKDDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS
  
Inhibitor
Name:
BDBM50505574
Synonyms:
CHEMBL4451634
Type:
Small organic molecule
Emp. Form.:
C42H58N8O4
Mol. Mass.:
738.9611
SMILES:
CC1(C)C(N)=Nc2cc(OCCCN3Cc4ccc(OCCc5cn(CC(=O)N6CCC(CCN7CCCC7)CC6)nn5)cc4C3)c(OCC3CC3)cc12 |c:4|
Structure:
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