Reaction Details Report a problem with these data
Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50007980
Substrate
n/a
Meas. Tech.
ChEMBL_47961 (CHEMBL656249)
IC50
1200±n/a nM
Citation
Shiosaki, K; Lin, CW; Kopecka, H; Bianchi, B; Miller, T; Stashko, M; Witte, D Minor structural differences in Boc-CCK-4 derivatives dictate affinity and selectivity for CCK-A and CCK-B receptors. J Med Chem 40:1169-72 (1997) [PubMed] Article
More Info.:
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48445.79
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-2 receptors in HEK 293 cells.
Residue:
447
Sequence:
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
Inhibitor
Name:
BDBM50007980
Synonyms:
3-[(S)-2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-p-tolyl-ureido)-hexanoylamino]-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | 3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-p-tolyl-ureido)-hexanoylamino]-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | CHEMBL17534
Type:
Small organic molecule
Emp. Form.:
C43H54N8O9
Mol. Mass.:
826.9371
SMILES:
Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc2ccccc2)C(N)=O)cc1