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Target
Phosphatidylinositol 4-kinase beta
Ligand
BDBM50506070
Substrate
n/a
Meas. Tech.
ChEMBL_1824743 (CHEMBL4324507)
IC50
2160±n/a nM
Citation
 Tassini, S; Langron, E; Delang, L; Mirabelli, C; Lanko, K; Crespan, E; Kissova, M; Tagliavini, G; Fontò, G; Bertoni, S; Palese, S; Giorgio, C; Ravanetti, F; Ragionieri, L; Zamperini, C; Mancini, A; Dreassi, E; Maga, G; Vergani, P; Neyts, J; Radi, M Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach ?. J Med Chem 62:10833-10847 (2019) [PubMed]  Article 
Target
Name:
Phosphatidylinositol 4-kinase beta
Synonyms:
NPIK | PI4-kinase beta subunit | PI4K-beta | PI4K92 | PI4KB | PI4KB_HUMAN | PI4Kbeta | PIK4B | PIK4CB | Phosphatidylinositol 4-kinase beta | Phosphatidylinositol 4-kinase, PI4K | PtdIns 4-kinase beta
Type:
Protein
Mol. Mass.:
91373.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
816
Sequence:
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
  
Inhibitor
Name:
BDBM50506070
Synonyms:
CHEMBL4461468
Type:
Small organic molecule
Emp. Form.:
C12H12N4O2S2
Mol. Mass.:
308.379
SMILES:
CC(=O)Nc1nc(C)c(s1)-c1csc(NC(=O)C=C)n1
Structure:
Search PDB for entries with ligand similarity: