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Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50506547
Substrate
n/a
Meas. Tech.
ChEMBL_1826276 (CHEMBL4326150)
Ki
16±n/a nM
Citation
 Iwamura, R; Tanaka, M; Okanari, E; Kirihara, T; Odani-Kawabata, N; Shams, N; Yoneda, K Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl. J Med Chem 61:6869-6891 (2018) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Homo sapiens (Human)
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM50506547
Synonyms:
C-533,536-02 | CP-533536-02 | Evatanepag sodium
Type:
Small organic molecule
Emp. Form.:
C25H27N2NaO5S
Mol. Mass.:
490.547
SMILES:
[Na;v0+].[#6]C([#6])([#6])c1ccc(-[#6]-[#7](-[#6]-c2cccc(-[#8]-[#6]-[#6](-[#8-])=O)c2)S(=O)(=O)c2cccnc2)cc1
Structure:
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