Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50506559
Substrate
n/a
Meas. Tech.
ChEMBL_1826277 (CHEMBL4326151)
EC50
649±n/a nM
Citation
 Iwamura, R; Tanaka, M; Okanari, E; Kirihara, T; Odani-Kawabata, N; Shams, N; Yoneda, K Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl. J Med Chem 61:6869-6891 (2018) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Homo sapiens (Human)
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM50506559
Synonyms:
CHEMBL4514124
Type:
Small organic molecule
Emp. Form.:
C24H35ClN4O4S
Mol. Mass.:
511.077
SMILES:
Cl.CC(C)(C)C1CCC(CN(Cc2cccc(NCC(O)=O)n2)S(=O)(=O)c2cccnc2)CC1 |(25.24,-7.37,;27.32,-14.13,;27.32,-12.59,;28.65,-11.82,;28.65,-13.35,;25.98,-11.82,;24.65,-12.59,;23.32,-11.82,;23.32,-10.28,;21.99,-9.51,;20.65,-10.29,;19.32,-9.52,;19.31,-7.98,;17.98,-7.22,;17.97,-5.69,;19.3,-4.9,;20.64,-5.67,;21.96,-4.89,;23.3,-5.65,;24.63,-4.87,;24.62,-3.33,;25.97,-5.64,;20.65,-7.21,;20.66,-11.82,;22.2,-11.82,;21.43,-13.16,;19.32,-12.6,;19.33,-14.15,;18,-14.92,;16.66,-14.15,;16.67,-12.61,;17.99,-11.84,;24.64,-9.51,;25.98,-10.28,)|
Structure:
Search PDB for entries with ligand similarity: