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Target
Serine/threonine-protein kinase A-Raf
Ligand
BDBM50085415
Substrate
n/a
Meas. Tech.
ChEMBL_1828436 (CHEMBL4328310)
IC50
14.6±n/a nM
Citation
 Narayan, S; Ramisetti, S; Jaiswal, AS; Law, BK; Singh-Pillay, A; Singh, P; Amin, S; Sharma, AK ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells. Eur J Med Chem 161:456-467 (2019) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase A-Raf
Synonyms:
ARAF | ARAF1 | ARAF_HUMAN | PKS | PKS2 | Proto-oncogene A-Raf | Proto-oncogene A-Raf-1 | Proto-oncogene Pks | RAF serine/threonine protein kinase
Type:
Enzyme
Mol. Mass.:
67610.81
Organism:
Homo sapiens (Human)
Description:
P10398
Residue:
606
Sequence:
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP
  
Inhibitor
Name:
BDBM50085415
Synonyms:
3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one | 3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one | 3-[1-(3,5-Dibromo-4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-iodo-1,3-dihydro-indol-2-one | CHEMBL72365 | G6416 (GW5074) | GW-5074
Type:
Small organic molecule
Emp. Form.:
C15H8Br2INO2
Mol. Mass.:
520.942
SMILES:
Oc1c(Br)cc(\C=C2/C(=O)Nc3ccc(I)cc23)cc1Br
Structure:
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