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Target
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Ligand
BDBM50506982
Substrate
n/a
Meas. Tech.
ChEMBL_1828853 (CHEMBL4328727)
Ki
32±n/a nM
Citation
 Najjar, A; Platzer, C; Luft, A; Aßmann, CA; Elghazawy, NH; Erdmann, F; Sippl, W; Schmidt, M Computer-aided design, synthesis and biological characterization of novel inhibitors for PKMYT1. Eur J Med Chem 161:479-492 (2019) [PubMed]  Article 
Target
Name:
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Synonyms:
MYT1 | PKMYT1 | PMYT1_HUMAN | Tyrosine- and threonine-specific cdc2-inhibitory kinase
Type:
PROTEIN
Mol. Mass.:
54523.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_587209
Residue:
499
Sequence:
MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT
  
Inhibitor
Name:
BDBM50506982
Synonyms:
CHEMBL533960 | D3RKN_89
Type:
Small organic molecule
Emp. Form.:
C24H26N8O2
Mol. Mass.:
458.5156
SMILES:
COc1ccc(Nc2ncc(C#N)c(Nc3ccccc3C(N)=O)n2)cc1N1CCN(C)CC1
Structure:
Search PDB for entries with ligand similarity: