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Target
Lactoperoxidase
Ligand
BDBM50507390
Substrate
n/a
Meas. Tech.
ChEMBL_1829877 (CHEMBL4329751)
IC50
>8000±n/a nM
Citation
 Wurtz, NR; Viet, A; Shaw, SA; Dilger, A; Valente, MN; Khan, JA; Jusuf, S; Narayanan, R; Fernando, G; Lo, F; Liu, X; Locke, GA; Kopcho, L; Abell, LM; Sleph, P; Basso, M; Zhao, L; Wexler, RR; Duclos, F; Kick, EK Potent Triazolopyridine Myeloperoxidase Inhibitors. ACS Med Chem Lett 9:1175-1180 (2018) [PubMed]  Article 
Target
Name:
Lactoperoxidase
Synonyms:
LPO | PERL_HUMAN | SAPX
Type:
PROTEIN
Mol. Mass.:
80305.60
Organism:
Homo sapiens (Human)
Description:
ChEMBL_493330
Residue:
712
Sequence:
MRVLLHLPALLASLILLQAAASTTRAQTTRTSAISDTVSQAKVQVNKAFLDSRTRLKTAMSSETPTSRQLSEYLKHAKGRTRTAIRNGQVWEESLKRLRQKASLTNVTDPSLDLTSLSLEVGCGAPAPVVRCDPCSPYRTITGDCNNRRKPALGAANRALARWLPAEYEDGLSLPFGWTPGKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSEYSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGKCMPFFRAGFVCPTPPYKSLAREQINALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPSPCEFINTTARVPCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAFVQIITFRDYLPILLGDHMQKWIPPYQGYSESVDPRISNVFTFAFRFGHLEVPSSMFRLDENYQPWGPEPELPLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPTHRIHGFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYGTPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPGVFTNEQKDSLQKMSFSRLVCDNTRITKVPRDPFWANSYPYDFVDCSAIDKLDLSPWASVKN
  
Inhibitor
Name:
BDBM50507390
Synonyms:
CHEMBL4482878 | US10981879, Example 3
Type:
Small organic molecule
Emp. Form.:
C12H10FN5S
Mol. Mass.:
275.305
SMILES:
Nc1cc(SCc2ccccc2F)c2nn[nH]c2n1
Structure:
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