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Target
Thromboxane A2 receptor
Ligand
BDBM50060449
Substrate
n/a
Meas. Tech.
ChEMBL_207644 (CHEMBL811626)
IC50
740±n/a nM
Citation
 Tsuri, T; Honma, T; Hiramatsu, Y; Okada, T; Hashizume, H; Mitsumori, S; Inagaki, M; Arimura, A; Yasui, K; Asanuma, F; Kishino, J; Ohtani, M Bicyclo[2.2.1]heptane and 6,6-dimethylbicyclo[3.1.1]heptane derivatives: orally active, potent, and selective prostaglandin D2 receptor antagonists. J Med Chem 40:3504-7 (1997) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50060449
Synonyms:
(Z)-(R)-7-[(3R,4S,7S)-6,6-Dimethyl-2-(4-phenylazo-benzenesulfonylamino)-bicyclo[3.1.1]hept-3-yl]-hept-5-enoic acid | 7-[6,6-Dimethyl-2-(4-phenylazo-benzenesulfonylamino)-bicyclo[3.1.1]hept-3-yl]-hept-5-enoic acid | CHEMBL420404
Type:
Small organic molecule
Emp. Form.:
C28H35N3O4S
Mol. Mass.:
509.66
SMILES:
CC1(C)[C@@H]2C[C@H]1[C@H](NS(=O)(=O)c1ccc(cc1)\N=N\c1ccccc1)[C@@H](C\C=C/CCCC(O)=O)C2
Structure:
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