Reaction Details Report a problem with these data
Target
Plasmepsin IV [1-448]
Ligand
BDBM50507812
Substrate
n/a
Meas. Tech.
ChEMBL_1831639 (CHEMBL4331647)
IC50
38±n/a nM
Citation
 Zogota, R; Kinena, L; Withers-Martinez, C; Blackman, MJ; Bobrovs, R; Pantelejevs, T; Kanepe-Lapsa, I; Ozola, V; Jaudzems, K; Suna, E; Jirgensons, A Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D. Eur J Med Chem 163:344-352 (2019) [PubMed]  Article 
Target
Name:
Plasmepsin IV [1-448]
Synonyms:
PLM4_PLAF7 | PMIV | Plasmepsin 4 (PM-IV)
Type:
Enzyme
Mol. Mass.:
50925.00
Organism:
Plasmodium falciparum
Description:
Q8IM16[1-448]
Residue:
448
Sequence:
MALTVKEEEFSNTLIKNASAFDRLKLGNLKNLKIQKKLQFLYLILFVLITGVFFFFLIGNFYSHRKLYQVIKNTKHTTIGFKIDRPHDKVLSSVLKNKLSTYVKESFKFFKSGYAQKGYLGSENDSIELDDVANLMFYGEGQIGTNKQPFMFIFDTGSANLWVPSVNCDSIGCSTKHLYDASASKSYEKDGTKVEISYGSGTVRGYFSKDVISLGDLSLPYKFIEVTDADDLEPIYSGSEFDGILGLGWKDLSIGSIDPVVVELKKQNKIDNALFTFYLPVHDKHVGYLTIGGIESDFYEGPLTYEKLNHDLYWQIDLDIHFGKYVMQKANAVVDSGTSTITAPTSFLNKFFRDMNVIKVPFLPLYVTTCDNDDLPTLEFHSRNNKYTLEPEFYMDPLSDIDPALCMLYILPVDIDDNTFILGDPFMRKYFTVFDYEKESVGFAVAKN
  
Inhibitor
Name:
BDBM50507812
Synonyms:
CHEMBL4470195
Type:
Small organic molecule
Emp. Form.:
C40H48N4O4
Mol. Mass.:
648.8335
SMILES:
COc1cccc(c1)C(C)(C)NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc(cc(c1)C(=O)NCc1ccccc1)N1CCCCC1 |r|
Structure:
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