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Target
Dihydrofolate reductase
Ligand
BDBM50027970
Substrate
n/a
Meas. Tech.
ChEMBL_52851 (CHEMBL664375)
IC50
31±n/a nM
Citation
 Rosowsky, A; Papoulis, AT; Queener, SF 2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. J Med Chem 40:3694-9 (1997) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
23891.29
Organism:
Pneumocystis carinii
Description:
n/a
Residue:
206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL
  
Inhibitor
Name:
BDBM50027970
Synonyms:
5-(4-Bromo-3,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine | Brodimoprim | CHEMBL31891
Type:
Small organic molecule
Emp. Form.:
C13H15BrN4O2
Mol. Mass.:
339.188
SMILES:
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1Br
Structure:
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