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Target
Dihydrofolate reductase
Ligand
BDBM50027970
Substrate
n/a
Meas. Tech.
ChEMBL_54964 (CHEMBL666695)
IC50
15±n/a nM
Citation
 Rosowsky, A; Papoulis, AT; Queener, SF 2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. J Med Chem 40:3694-9 (1997) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21638.84
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50027970
Synonyms:
5-(4-Bromo-3,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine | Brodimoprim | CHEMBL31891
Type:
Small organic molecule
Emp. Form.:
C13H15BrN4O2
Mol. Mass.:
339.188
SMILES:
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1Br
Structure:
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