Reaction Details Report a problem with these data
Target
Estrogen receptor
Ligand
BDBM50508062
Substrate
n/a
Meas. Tech.
ChEMBL_1832075 (CHEMBL4332083)
EC50
1.5±n/a nM
Citation
 Govek, SP; Bonnefous, C; Julien, JD; Nagasawa, JY; Kahraman, M; Lai, AG; Douglas, KL; Aparicio, AM; Darimont, BD; Grillot, KL; Joseph, JD; Kaufman, JA; Lee, KJ; Lu, N; Moon, MJ; Prudente, RY; Sensintaffar, J; Rix, PJ; Hager, JH; Smith, ND Selective estrogen receptor degraders with novel structural motifs induce regression in a tamoxifen-resistant breast cancer xenograft. Bioorg Med Chem Lett 29:367-372 (2019) [PubMed]  Article 
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM50508062
Synonyms:
CHEMBL4560511
Type:
Small organic molecule
Emp. Form.:
C28H22ClFN2O2
Mol. Mass.:
472.938
SMILES:
OC(=O)\C=C\c1ccc(cc1)C(=C(\C1CCC1)c1ccc(F)cc1Cl)\c1ccc2nccn2c1
Structure:
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