Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50508690
Substrate
n/a
Meas. Tech.
ChEMBL_1833775 (CHEMBL4333783)
Ki
51±n/a nM
Citation
 Varano, F; Catarzi, D; Falsini, M; Dal Ben, D; Buccioni, M; Marucci, G; Volpini, R; Colotta, V Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity. Bioorg Med Chem Lett 29:563-569 (2019) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50508690
Synonyms:
CHEMBL4529321
Type:
Small organic molecule
Emp. Form.:
C15H10N4O2S
Mol. Mass.:
310.331
SMILES:
Nc1nc(nc2sc(nc12)-c1ccco1)-c1cccc(O)c1
Structure:
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