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Target
Translocator protein
Ligand
BDBM50509023
Substrate
n/a
Meas. Tech.
ChEMBL_1837171 (CHEMBL4337304)
Ki
201±n/a nM
Citation
 Cheng, HWA; Sokias, R; Werry, EL; Ittner, LM; Reekie, TA; Du, J; Gao, Q; Hibbs, DE; Kassiou, M First Nondiscriminating Translocator Protein Ligands Produced from a Carbazole Scaffold. J Med Chem 62:8235-8248 (2019) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN
Type:
Enzyme
Mol. Mass.:
18834.74
Organism:
Homo sapiens (Human)
Description:
P30536
Residue:
169
Sequence:
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
  
Inhibitor
Name:
BDBM50509023
Synonyms:
CHEMBL4535242
Type:
Small organic molecule
Emp. Form.:
C29H25ClN2O2
Mol. Mass.:
468.974
SMILES:
COc1cccc(CN(C)C(=O)Cn2c3ccccc3c3cc(ccc23)-c2cccc(Cl)c2)c1
Structure:
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