Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50054139
Substrate
n/a
Meas. Tech.
ChEMBL_1837183 (CHEMBL4337316)
Ki
14±n/a nM
Citation
 Cheng, HWA; Sokias, R; Werry, EL; Ittner, LM; Reekie, TA; Du, J; Gao, Q; Hibbs, DE; Kassiou, M First Nondiscriminating Translocator Protein Ligands Produced from a Carbazole Scaffold. J Med Chem 62:8235-8248 (2019) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN
Type:
Enzyme
Mol. Mass.:
18834.74
Organism:
Homo sapiens (Human)
Description:
P30536
Residue:
169
Sequence:
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
  
Inhibitor
Name:
BDBM50054139
Synonyms:
(R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic acid sec-butyl-methyl-amide
Type:
Small organic molecule
Emp. Form.:
C21H21ClN2O
Mol. Mass.:
352.857
SMILES:
CC[C@@H](C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Structure:
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