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Target
Translocator protein
Ligand
BDBM50509027
Substrate
n/a
Meas. Tech.
ChEMBL_1837184 (CHEMBL4337317)
Ki
23±n/a nM
Citation
 Cheng, HWA; Sokias, R; Werry, EL; Ittner, LM; Reekie, TA; Du, J; Gao, Q; Hibbs, DE; Kassiou, M First Nondiscriminating Translocator Protein Ligands Produced from a Carbazole Scaffold. J Med Chem 62:8235-8248 (2019) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN
Type:
Enzyme
Mol. Mass.:
18834.74
Organism:
Homo sapiens (Human)
Description:
P30536
Residue:
169
Sequence:
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
  
Inhibitor
Name:
BDBM50509027
Synonyms:
CHEMBL4459176
Type:
Small organic molecule
Emp. Form.:
C30H28N2O3
Mol. Mass.:
464.5549
SMILES:
COc1ccc(cc1)-c1ccc2n(CC(=O)N(C)Cc3cccc(OC)c3)c3ccccc3c2c1
Structure:
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