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Target
Neutrophil collagenase
Ligand
BDBM50062478
Substrate
n/a
Meas. Tech.
ChEMBL_105076 (CHEMBL711321)
Ki
540±n/a nM
Citation
 Graf von Roedern, E; Grams, F; Brandstetter, H; Moroder, L Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8). J Med Chem 41:339-45 (1998) [PubMed]  Article 
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50062478
Synonyms:
CHEMBL116641 | N-Hydroxy-2-isobutyl-N'-(3-phenyl-propyl)-malonamide | N1-hydroxy-2-isobutyl-N3-(3-phenylpropyl)malonamide
Type:
Small organic molecule
Emp. Form.:
C16H24N2O3
Mol. Mass.:
292.3734
SMILES:
CC(C)CC(C(=O)NO)C(=O)NCCCc1ccccc1
Structure:
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