Reaction Details
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Cholesterol side-chain cleavage enzyme, mitochondrial
Ligand
BDBM50509323
Substrate
n/a
Meas. Tech.
ChEMBL_1837923 (CHEMBL4338056)
IC50
1000±n/a nM
Citation
Jiao, WH; Salim, AA; Khalil, ZG; Dewapriya, P; Lin, HW; Butler, MS; Capon, RJ Trivirensols: Selectively Bacteriostatic Sesquiterpene Trimers from the Australian Termite Nest-Derived Fungus J Nat Prod 82:3165-3175 (2019) [PubMed] Article More Info.:
Target
Name:
Cholesterol side-chain cleavage enzyme, mitochondrial
Synonyms:
CP11A_RAT | Cyp11a | Cyp11a-1 | Cyp11a1 | Cytochrome P450 11A1
Type:
PROTEIN
Mol. Mass.:
60603.33
Organism:
Rattus norvegicus
Description:
ChEMBL_50353
Residue:
526
Sequence:
MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINLYHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMESVYILDPKDAATLFSCEGPNPERYLVPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMGRESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLGSTMPRKGDTV
Inhibitor
Name:
BDBM50509323
Synonyms:
CHEMBL4436622
Type:
Small organic molecule
Emp. Form.:
C45H62O16
Mol. Mass.:
858.9642
SMILES:
[H][C@]12C=C(COC(=O)[C@]1([H])[C@](O)(COC(=O)C(\CO)=C\[C@@H]1[C@H](CC[C@@](O)(COC(=O)C(\CO)=C\[C@@H]3[C@H](CCC4=C3C(=O)OC4)C(C)C)[C@H]1C(O)=O)C(C)C)CC[C@@H]2C(C)C)C(O)=O |r,c:2,39|
Structure:
