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Target
D(2) dopamine receptor
Ligand
BDBM50063295
Substrate
n/a
Meas. Tech.
ChEMBL_60370 (CHEMBL672206)
Ki
5.7±n/a nM
Citation
 Wustrow, D; Belliotti, T; Glase, S; Kesten, SR; Johnson, D; Colbry, N; Rubin, R; Blackburn, A; Akunne, H; Corbin, A; Davis, MD; Georgic, L; Whetzel, S; Zoski, K; Heffner, T; Pugsley, T; Wise, L Aminopyrimidines with high affinity for both serotonin and dopamine receptors. J Med Chem 41:760-71 (1998) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50063295
Synonyms:
CHEMBL165664 | [4-(4-Phenyl-piperazin-1-ylmethyl)-cyclohexyl]-pyrimidin-2-yl-amine
Type:
Small organic molecule
Emp. Form.:
C21H29N5
Mol. Mass.:
351.4885
SMILES:
C([C@H]1CC[C@@H](CC1)Nc1ncccn1)N1CCN(CC1)c1ccccc1 |wU:4.7,wD:1.0,(7.44,-9.5,;6.6,-8.2,;7.3,-6.83,;6.46,-5.54,;4.91,-5.61,;4.22,-6.99,;5.06,-8.3,;4.07,-4.33,;4.76,-2.95,;3.91,-1.67,;4.61,-.29,;6.16,-.21,;7,-1.5,;6.3,-2.88,;8.98,-9.41,;9.69,-8.05,;11.21,-7.96,;12.06,-9.26,;11.37,-10.64,;9.83,-10.71,;13.6,-9.17,;14.43,-10.46,;15.96,-10.37,;16.66,-9.01,;15.81,-7.72,;14.28,-7.81,)|
Structure:
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