Target
D(3) dopamine receptor
Ligand
BDBM50063278
Substrate
n/a
Meas. Tech.
ChEMBL_62432 (CHEMBL674835)
Ki
40±n/a nM
Citation
 Wustrow, DBelliotti, TGlase, SKesten, SRJohnson, DColbry, NRubin, RBlackburn, AAkunne, HCorbin, ADavis, MDGeorgic, LWhetzel, SZoski, KHeffner, TPugsley, TWise, L Aminopyrimidines with high affinity for both serotonin and dopamine receptors. J Med Chem 41:760-71 (1998) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50063278
Synonyms:
CHEMBL165440 | {4-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-ethyl]-cyclohexyl}-pyrimidin-2-yl-amine
Type:
Small organic molecule
Emp. Form.:
C21H28N4
Mol. Mass.:
336.4738
SMILES:
C(CN1CCc2ccccc2C1)[C@H]1CC[C@@H](CC1)Nc1ncccn1 |wU:15.20,wD:12.13,(10.31,-5.42,;11.15,-6.7,;12.69,-6.63,;13.39,-5.25,;14.9,-5.18,;15.74,-6.44,;17.26,-6.35,;18.12,-7.61,;17.47,-9.01,;15.93,-9.12,;15.07,-7.84,;13.53,-7.91,;8.77,-5.49,;7.93,-4.2,;6.42,-4.27,;5.7,-5.65,;6.53,-6.93,;8.07,-6.86,;4.16,-5.72,;3.32,-4.41,;4.04,-3.06,;3.2,-1.76,;1.66,-1.83,;.96,-3.2,;1.8,-4.51,)|
Structure:
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