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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50063295
Substrate
n/a
Meas. Tech.
ChEMBL_1451 (CHEMBL616575)
Ki
41±n/a nM
Citation
 Wustrow, D; Belliotti, T; Glase, S; Kesten, SR; Johnson, D; Colbry, N; Rubin, R; Blackburn, A; Akunne, H; Corbin, A; Davis, MD; Georgic, L; Whetzel, S; Zoski, K; Heffner, T; Pugsley, T; Wise, L Aminopyrimidines with high affinity for both serotonin and dopamine receptors. J Med Chem 41:760-71 (1998) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50063295
Synonyms:
CHEMBL165664 | [4-(4-Phenyl-piperazin-1-ylmethyl)-cyclohexyl]-pyrimidin-2-yl-amine
Type:
Small organic molecule
Emp. Form.:
C21H29N5
Mol. Mass.:
351.4885
SMILES:
C([C@H]1CC[C@@H](CC1)Nc1ncccn1)N1CCN(CC1)c1ccccc1 |wU:4.7,wD:1.0,(7.44,-9.5,;6.6,-8.2,;7.3,-6.83,;6.46,-5.54,;4.91,-5.61,;4.22,-6.99,;5.06,-8.3,;4.07,-4.33,;4.76,-2.95,;3.91,-1.67,;4.61,-.29,;6.16,-.21,;7,-1.5,;6.3,-2.88,;8.98,-9.41,;9.69,-8.05,;11.21,-7.96,;12.06,-9.26,;11.37,-10.64,;9.83,-10.71,;13.6,-9.17,;14.43,-10.46,;15.96,-10.37,;16.66,-9.01,;15.81,-7.72,;14.28,-7.81,)|
Structure:
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