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Target
D(2) dopamine receptor
Ligand
BDBM50063287
Substrate
n/a
Meas. Tech.
ChEMBL_60370 (CHEMBL672206)
Ki
39±n/a nM
Citation
 Wustrow, D; Belliotti, T; Glase, S; Kesten, SR; Johnson, D; Colbry, N; Rubin, R; Blackburn, A; Akunne, H; Corbin, A; Davis, MD; Georgic, L; Whetzel, S; Zoski, K; Heffner, T; Pugsley, T; Wise, L Aminopyrimidines with high affinity for both serotonin and dopamine receptors. J Med Chem 41:760-71 (1998) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50063287
Synonyms:
CHEMBL164979 | {4-[2-(Methyl-phenethyl-amino)-ethyl]-cyclohexyl}-pyrimidin-2-yl-amine
Type:
Small organic molecule
Emp. Form.:
C21H30N4
Mol. Mass.:
338.4897
SMILES:
CN(CC[C@H]1CC[C@@H](CC1)Nc1ncccn1)CCc1ccccc1 |wU:7.10,wD:4.3,(13.32,-3.92,;12.62,-5.3,;11.08,-5.37,;10.24,-4.09,;8.7,-4.16,;7.86,-2.87,;6.35,-2.94,;5.63,-4.32,;6.46,-5.6,;8,-5.53,;4.09,-4.39,;3.25,-3.08,;3.97,-1.73,;3.13,-.43,;1.59,-.5,;.89,-1.87,;1.73,-3.18,;13.46,-6.58,;14.97,-6.51,;15.81,-7.79,;17.35,-7.72,;18.19,-9.01,;17.49,-10.38,;15.95,-10.45,;15.11,-9.17,)|
Structure:
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