Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50509923
Substrate
n/a
Meas. Tech.
ChEMBL_1839746 (CHEMBL4339961)
Ki
169±n/a nM
Citation
 Dou, F; Cao, X; Jing, P; Wu, C; Zhang, Y; Chen, Y; Zhang, G Synthesis and evaluation of histamine H Bioorg Med Chem Lett 29:1492-1496 (2019) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50509923
Synonyms:
CHEMBL4456092
Type:
Small organic molecule
Emp. Form.:
C17H24N2O2
Mol. Mass.:
288.3847
SMILES:
CN1CCc2ccc(OCCCN3CCCC3)cc2C1=O
Structure:
Search PDB for entries with ligand similarity: