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Target
V-type proton ATPase 116 kDa subunit a 1
Ligand
BDBM50064184
Substrate
n/a
Meas. Tech.
ChEMBL_210946 (CHEMBL813070)
IC50
100±n/a nM
Citation
 Gagliardi, S; Nadler, G; Consolandi, E; Parini, C; Morvan, M; Legave, MN; Belfiore, P; Zocchetti, A; Clarke, GD; James, I; Nambi, P; Gowen, M; Farina, C 5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity. J Med Chem 41:1568-73 (1998) [PubMed]  Article 
Target
Name:
V-type proton ATPase 116 kDa subunit a 1
Synonyms:
ATP6V0A1 | VPP1_CHICK | Vacuolar H(+)-transporting ATPase 116 kDa subunit, a1 isoform
Type:
PROTEIN
Mol. Mass.:
95982.67
Organism:
Gallus gallus
Description:
ChEMBL_210941
Residue:
838
Sequence:
MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIKKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLEESSSLLEPSEMGRGAPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLSAEVWCPVADLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTCGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLIAIWMVLRESRILSQKSDNEMFSTVFSGRYIILLMGLFSTYTGLIYNDCFSKSLNMFGSSWSVRPMFSKANWSDELLKTTPLLQLDPAEAGVFGGPYPFGIDPIWNIANNKLAFLNSFKMKMSVILGIIHMLFGVMLSLLNHIYFKKPLNIYLGFIPEMIFMSSLFGYLVILIFYKWTAYDAHTSKEAPSPLIHFINMFLFSYGDTSNKMLYRGQKGIQCFLVVVALLCVPWMLVAKPLVLRHQYLRRKHLGTHNFGGIRVGNGPTEEDAEIIQHDQLSTHSEEGEEPTEDEVFDFADTVVYQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHTGLSVRSLAGGFGLVFIFAAFATLTVAILLVMEGLSAFLHALRLHWIEFQNKFYTGTGFKFLPFSFDPIREGKFDD
  
Inhibitor
Name:
BDBM50064184
Synonyms:
(2Z,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-penta-2,4-dienoic acid ((1S,5R)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide | CHEMBL288419
Type:
Small organic molecule
Emp. Form.:
C22H25Cl2N3O2
Mol. Mass.:
434.359
SMILES:
CO\C(=C/C=C/c1cc2cc(Cl)c(Cl)cc2[nH]1)C(=O)NC1C[C@@H]2CC[C@H](C1)N2C |THB:28:27:20.21.26:23.24|
Structure:
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