Reaction Details Report a problem with these data
Target
Prolyl 4-hydroxylase
Ligand
BDBM50431015
Substrate
n/a
Meas. Tech.
ChEMBL_1840409 (CHEMBL4340708)
IC50
5000±n/a nM
Citation
 Langley, GW; Abboud, MI; Lohans, CT; Schofield, CJ Inhibition of a viral prolyl hydroxylase. Bioorg Med Chem 27:2405-2412 (2019) [PubMed]  Article 
Target
Name:
Prolyl 4-hydroxylase
Synonyms:
A085R | Prolyl 4-hydroxylase
Type:
PROTEIN
Mol. Mass.:
27815.10
Organism:
Paramecium bursaria Chlorella virus 1
Description:
ChEMBL_119118
Residue:
242
Sequence:
MTNKFISYNKMETREYLLTILFVIACFMVLNLERREGFETSDRPGVCDGKYYEKIDGFLSDIECDVLINAAIKKGLIKSEVGGATENDPIKLDPKSRNSEQTWFMPGEHEVIDKIQKKTREFLNSKKHCIDKYNFEDVQVARYKPGQYYYHHYDGDDCDDACPKDQRLATLMVYLKAPEEGGGGETDFPTLKTKIKPKKGTSIFFWVADPVTRKLYKETLHAGLPVKSGEKIIANQWIRAVK
  
Inhibitor
Name:
BDBM50431015
Synonyms:
CHEMBL2338329 | US10889546, FG-4592 | US9115085, Compound A Form A | US9340511, 3
Type:
Small organic molecule
Emp. Form.:
C19H16N2O5
Mol. Mass.:
352.3407
SMILES:
Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccccc3)cc12
Structure:
Search PDB for entries with ligand similarity: