Reaction Details Report a problem with these data
Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50454975
Substrate
n/a
Meas. Tech.
ChEMBL_28347 (CHEMBL643358)
IC50
27±n/a nM
Citation
 Tanaka, A; Terasawa, T; Hagihara, H; Sakuma, Y; Ishibe, N; Sawada, M; Takasugi, H; Tanaka, H Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylureas. J Med Chem 41:2390-410 (1998) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50454975
Synonyms:
CHEMBL78737
Type:
Small organic molecule
Emp. Form.:
C27H29N5OS2
Mol. Mass.:
503.682
SMILES:
CSc1cc(C)nc(SC)c1NC(=O)N(Cc1ccccc1)Cc1ccc(cc1)-c1ccnn1C
Structure:
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