Reaction Details Report a problem with these data
Target
Platelet-activating factor receptor
Ligand
BDBM50065337
Substrate
n/a
Meas. Tech.
ChEMBL_158346 (CHEMBL768490)
IC50
12000±n/a nM
Citation
 Han, BH; Yang, HO; Kang, YH; Suh, DY; Go, HJ; Song, WJ; Kim, YC; Park, MK In vitro platelet-activating factor receptor binding inhibitory activity of pinusolide derivatives: a structure-activity study. J Med Chem 41:2626-30 (1998) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50065337
Synonyms:
(1S,4aR,5S)-5-((Z)-5-Hydroxy-3-hydroxymethyl-pent-3-enyl)-1,4a-dimethyl-6-methylene-decahydro-naphthalene-1-carboxylic acid methyl ester | CHEMBL89784
Type:
Small organic molecule
Emp. Form.:
C21H34O4
Mol. Mass.:
350.4923
SMILES:
COC(=O)[C@@]1(C)CCC[C@]2(C)[C@@H](CC\C(CO)=C\CO)C(=C)CCC12
Structure:
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