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Target
Perforin-1
Ligand
BDBM50510959
Substrate
n/a
Meas. Tech.
ChEMBL_1842689 (CHEMBL4343116)
IC50
>20000±n/a nM
Citation
 Spicer, JA; Miller, CK; O'Connor, PD; Jose, J; Giddens, AC; Jaiswal, JK; Jamieson, SMF; Bull, MR; Denny, WA; Akhlaghi, H; Trapani, JA; Hill, GR; Chang, K; Gartlan, KH Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo. J Med Chem 63:2229-2239 (2020) [PubMed]  Article 
Target
Name:
Perforin-1
Synonyms:
PERF_HUMAN | PFP | PRF1
Type:
PROTEIN
Mol. Mass.:
61392.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1285138
Residue:
555
Sequence:
MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW
  
Inhibitor
Name:
BDBM50510959
Synonyms:
CHEMBL4530394
Type:
Small organic molecule
Emp. Form.:
C30H29F2N5O3S2
Mol. Mass.:
609.71
SMILES:
CN1CCN(CCN2Cc3cc(ccc3C2=O)-c2ccc(s2)-c2cncc(NS(=O)(=O)c3ccc(F)cc3F)c2)CC1
Structure:
Search PDB for entries with ligand similarity: