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Target
Perforin-1
Ligand
BDBM50510954
Substrate
n/a
Meas. Tech.
ChEMBL_1842690 (CHEMBL4343117)
IC50
3400±n/a nM
Citation
 Spicer, JA; Miller, CK; O'Connor, PD; Jose, J; Giddens, AC; Jaiswal, JK; Jamieson, SMF; Bull, MR; Denny, WA; Akhlaghi, H; Trapani, JA; Hill, GR; Chang, K; Gartlan, KH Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo. J Med Chem 63:2229-2239 (2020) [PubMed]  Article 
Target
Name:
Perforin-1
Synonyms:
PERF_HUMAN | PFP | PRF1
Type:
PROTEIN
Mol. Mass.:
61392.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1285138
Residue:
555
Sequence:
MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW
  
Inhibitor
Name:
BDBM50510954
Synonyms:
CHEMBL4452449
Type:
Small organic molecule
Emp. Form.:
C24H17F3N4O3S2
Mol. Mass.:
530.542
SMILES:
CN1Cc2cc(cnc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2cccc(c2)C(F)(F)F)c1
Structure:
Search PDB for entries with ligand similarity: