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Target
Endothelin-1 receptor
Ligand
BDBM50065553
Substrate
n/a
Meas. Tech.
ChEMBL_63348 (CHEMBL679113)
IC50
6000±n/a nM
Citation
 Astles, PC; Brown, TJ; Halley, F; Handscombe, CM; Harris, NV; McCarthy, C; McLay, IM; Lockey, P; Majid, T; Porter, B; Roach, AG; Smith, C; Walsh, R Selective endothelin A receptor antagonists. 4. Discovery and structure-activity relationships of stilbene acid and alcohol derivatives. J Med Chem 41:2745-53 (1998) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50065553
Synonyms:
(E)-3-(3-Benzyloxy-phenyl)-2-phenyl-acrylic acid | CHEMBL92607
Type:
Small organic molecule
Emp. Form.:
C22H18O3
Mol. Mass.:
330.3765
SMILES:
OC(=O)C(=C\c1cccc(OCc2ccccc2)c1)\c1ccccc1
Structure:
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