Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50065793
Substrate
n/a
Meas. Tech.
ChEMBL_90696 (CHEMBL702097)
IC50
300±n/a nM
Citation
Mekouar, K; Mouscadet, JF; Desmaële, D; Subra, F; Leh, H; Savouré, D; Auclair, C; d'Angelo, J Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells. J Med Chem 41:2846-57 (1998) [PubMed] Article
More Info.:
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
Inhibitor
Name:
BDBM50065793
Synonyms:
8-Hydroxy-2-[(E)-2-(3,4,5-trihydroxy-phenyl)-vinyl]-quinoline-7-carboxylic acid | 8-Hydroxy-2-[2-(3,4,5-trihydroxy-phenyl)-vinyl]-quinoline-7-carboxylic acid | 8-hydroxy-2-(3,4,5-trihydroxystyryl)quinoline-7-carboxylic acid | CHEMBL37869
Type:
Small organic molecule
Emp. Form.:
C18H13NO6
Mol. Mass.:
339.2989
SMILES:
OC(=O)c1ccc2ccc(\C=C\c3cc(O)c(O)c(O)c3)nc2c1O