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Target
Integrase
Ligand
BDBM50065784
Substrate
n/a
Meas. Tech.
ChEMBL_90700 (CHEMBL702101)
IC50
>100000±n/a nM
Citation
 Mekouar, K; Mouscadet, JF; Desmaële, D; Subra, F; Leh, H; Savouré, D; Auclair, C; d'Angelo, J Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells. J Med Chem 41:2846-57 (1998) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50065784
Synonyms:
4-[(E)-2-(8-Nitro-quinolin-2-yl)-vinyl]-benzene-1,2-diol | 4-[2-(8-Nitro-quinolin-2-yl)-vinyl]-benzene-1,2-diol | CHEMBL61800
Type:
Small organic molecule
Emp. Form.:
C17H12N2O4
Mol. Mass.:
308.2882
SMILES:
Oc1ccc(\C=C\c2ccc3cccc([N+]([O-])=O)c3n2)cc1O
Structure:
Search PDB for entries with ligand similarity: