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Target
Integrase
Ligand
BDBM50065800
Substrate
n/a
Meas. Tech.
ChEMBL_90696 (CHEMBL702097)
IC50
>100000±n/a nM
Citation
 Mekouar, K; Mouscadet, JF; Desmaële, D; Subra, F; Leh, H; Savouré, D; Auclair, C; d'Angelo, J Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells. J Med Chem 41:2846-57 (1998) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50065800
Synonyms:
(E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid 2-methyl-quinolin-8-yl ester | 3-(3,4-Dihydroxy-phenyl)-acrylic acid 2-methyl-quinolin-8-yl ester | CHEMBL418303
Type:
Small organic molecule
Emp. Form.:
C19H15NO4
Mol. Mass.:
321.3267
SMILES:
Cc1ccc2cccc(OC(=O)\C=C\c3ccc(O)c(O)c3)c2n1
Structure:
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