Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50065790
Substrate
n/a
Meas. Tech.
ChEMBL_90700 (CHEMBL702101)
IC50
2800±n/a nM
Citation
Mekouar, K; Mouscadet, JF; Desmaële, D; Subra, F; Leh, H; Savouré, D; Auclair, C; d'Angelo, J Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells. J Med Chem 41:2846-57 (1998) [PubMed] Article
More Info.:
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
Inhibitor
Name:
BDBM50065790
Synonyms:
(E)-2-(2,4-dihydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid | 2-(2,4-dihydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid | 2-[(E)-2-(2,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid | 2-[2-(2,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid | CHEMBL36586
Type:
Small organic molecule
Emp. Form.:
C18H13NO5
Mol. Mass.:
323.2995
SMILES:
OC(=O)c1ccc2ccc(\C=C\c3ccc(O)cc3O)nc2c1O