Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM50511123
Substrate
n/a
Meas. Tech.
ChEMBL_1843889 (CHEMBL4344316)
Kd
920±n/a nM
Citation
 Kump, KJ; Miao, L; Mady, ASA; Ansari, NH; Shrestha, UK; Yang, Y; Pal, M; Liao, C; Perdih, A; Abulwerdi, FA; Chinnaswamy, K; Meagher, JL; Carlson, JM; Khanna, M; Stuckey, JA; Nikolovska-Coleska, Z Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins. J Med Chem 63:2489-2510 (2020) [PubMed]  Article 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM50511123
Synonyms:
CHEMBL4522193
Type:
Small organic molecule
Emp. Form.:
C29H35N3O4S2
Mol. Mass.:
553.736
SMILES:
CC(C)(C)c1ccc(cc1)N1CCN(CC1)S(=O)(=O)Nc1ccc(SCCc2ccccc2)cc1C(O)=O
Structure:
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