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Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50066101
Substrate
n/a
Meas. Tech.
ChEMBL_70198 (CHEMBL684262)
EC50
0.34±n/a nM
Citation
 Nargund, RP; Patchett, AA; Bach, MA; Murphy, MG; Smith, RG Peptidomimetic growth hormone secretagogues. Design considerations and therapeutic potential. J Med Chem 41:3103-27 (1998) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50066101
Synonyms:
CHEMBL322912 | Piperidine-4-carboxylic acid {(R)-1-[(R)-1-(carbamoylmethyl-phenethyl-carbamoyl)-2-naphthalen-2-yl-ethylcarbamoyl]-2-naphthalen-2-yl-ethyl}-amide | Piperidine-4-carboxylic acid {1-[1-(carbamoylmethyl-phenethyl-carbamoyl)-2-naphthalen-2-yl-ethylcarbamoyl]-2-naphthalen-2-yl-ethyl}-amide
Type:
Small organic molecule
Emp. Form.:
C42H45N5O4
Mol. Mass.:
683.8378
SMILES:
NC(=O)CN(CCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1
Structure:
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