Reaction Details Report a problem with these data
Target
Alpha-2B adrenergic receptor
Ligand
BDBM50511341
Substrate
n/a
Meas. Tech.
ChEMBL_1844619 (CHEMBL4345046)
IC50
790±n/a nM
Citation
 de Lucas, AI; Vega, JA; Matesanz, E; Linares, ML; García Molina, A; Tresadern, G; Lavreysen, H; Trabanco, AA; Cid, JM Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1 ACS Med Chem Lett 11:303-308 (2020) [PubMed]  Article 
Target
Name:
Alpha-2B adrenergic receptor
Synonyms:
ADA2B_HUMAN | ADRA2B | ADRA2L1 | ADRA2RL1 | Adrenergic alpha2B | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2B-, receptor [Homo sapiens] | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR
Type:
Enzyme
Mol. Mass.:
49964.20
Organism:
Homo sapiens (Human)
Description:
P18089
Residue:
450
Sequence:
MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
  
Inhibitor
Name:
BDBM50511341
Synonyms:
CHEMBL4483761
Type:
Small organic molecule
Emp. Form.:
C19H18BrF3N4O2
Mol. Mass.:
471.271
SMILES:
CCOc1cc(nnc1C(F)(F)F)N1CCC2(CC1)C(=O)Nc1ccc(Br)cc21
Structure:
Search PDB for entries with ligand similarity: