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Target
Integrase
Ligand
BDBM50066324
Substrate
n/a
Meas. Tech.
ChEMBL_88599 (CHEMBL701178)
IC50
>100000±n/a nM
Citation
 Neamati, N; Hong, H; Owen, JM; Sunder, S; Winslow, HE; Christensen, JL; Zhao, H; Burke, TR; Milne, GW; Pommier, Y Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site. J Med Chem 41:3202-9 (1998) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50066324
Synonyms:
CHEMBL321850 | Naphthalene-2-carboxylic acid N'-(2,4-dichloro-benzoyl)-hydrazide
Type:
Small organic molecule
Emp. Form.:
C18H12Cl2N2O2
Mol. Mass.:
359.206
SMILES:
Clc1ccc(C(=O)NNC(=O)c2ccc3ccccc3c2)c(Cl)c1
Structure:
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